| Russel | Russell | Russian | Russlins | Rutledge | Ry | Ryals |
| Ryan | Ryder | Rye | Rylander | Ryles | Rymer | Rymes |
| Ryner | Ryols | Sabo | Sadler | Sadlette | Saffold | Salette |
| Saley | Sallette | Salter | Salters | Sammis | Sammons | Sams |
| Sanches | Sanchez | Sandefur | Sander | Sanderlin | Sanderling | Sanders |
| Sandford | Sandley | Sandlin | Sandrich | Sands | Sanford | Sanita |
| Santarra | Santina | Santine | Santines | Santini | Santura | Sapp |
| Sapsley | Sarah | Sarlo | Sartain | sat | Satchell | Sater |
| Sattler | Sauls | Saunders | Savage | Savasuk | Sawyer | Sawyet |
| Saxon | Saxton | Scaggs | Scales | Scarbarough | Scarborough | Schaeufele |
| Schafer | Schenck | Schephard | Schley | Schmautz | Schmehl | Schmidt |
| Schneider | Schoep | Schofield | Schopeld | Schroeder | Schubert | Schultz |
| Schuman | Sciple | Scofield | Scoot | Scott | Seabrook | Seago |
| Seal | Sealey | Seals | Sealy | Seaman | Searle | Seastrong |
| Seat | Seaver | Sebendon | Seddlemeyer | Seely | Segrest | Seibert |
| Seiman | Sel | Self | Sellars | Selleck | Sellers | Sells |
| Selman | Selvidge | Seminoles | Semmes | Sergener | Sergenier | Serginer |
| Serin | Sermons | Sertz | Sessions | Sever | Seward | Sewell |
| Sextant | Sexton | Seymour | Shackelford | Shackleford | Shafer | Shaffer |
| Shain | Shanaham | Shanahan | Shands | Shank | Shannahan | Shannan |
| Shannon | Sharp | Sharpe | Sharpton | Shaver | Shavers | Shaw |
| Shearer | Sheaver | Sheets | Sheffield | Sheftall | Sheldon | Shelfer |
| Shelley | Shelton | Shepard | Sheperd | Shephard | Shepherd | Sheppard |
| Shepperd | Sheridan | Sherley | Sherman | Sherouse | Sherrille | Sherron |
| Sherrouse | Shield | Shields, | Shifflette | Shimer | Shimmer | Shingledecker |
| Ship | Shipman | Shipp | Shirah | Shirey | Shirley | Shirling |
| Shive | Shiver | Shoemaker | Shores | Short | Shotes | Shotwell |
| Shradle | Shriver | Shrontz | Shular | Shultz | Shuman | Shupp |
| Sias | SIbbald | Sibley | Sichter | Sigler | Sigrest | SiImmons |
| Sikes | Silcox | Silvester | Silvey | SIlvy | Simmon | Simmonds |
| Simmons | Simms | Simpson | Sims | Simson | Sinclair | Singer |
| Singletary | Singleton | Sirmans | Sission | Sistrunk | Sitler | Sivils |
| Sizemore | Skates | Skeim | Skinner | Skipper | Skitka | Skornschek |
| Slade | Slaughter | Sleeper | Slimmer | Sloan | Sloane | Slocum |
| Slocumb | Slone | Small | Smallwood | Smart | Smiley | Sminer |
| Smith | Smith, | Smithson | Smoke | Smoot | Smth | Smythe |
| Snead | Snell | Snelson | Snider | Snipes | Snodgrass | Snow |
| Snyder | Sola | Solar | Solomon | Solomons | Solon | Sorrells |
| Soto | Souerstrom | Southerland | Southgate | Southwell | Sowells | Spahler |
| Span | Spang | Sparklman | Sparkman | Sparkman, | Sparks | Spear |
| Spearing | Spearman | Speck | Speed | Speer | Speight | Spencer |
| Spences | Sperko | Spicer | Spier | Spires | Spivey | Spotford |
| Spottswood | Spratlin | Spratt | Spriggs | Springer | Sprinkle | Squire |
| Sried | St Lyn | St. Croix | Staats | Stacy | Stafford | Stallings |
| Stallins | Stallions | Stalls | Stalsvey | Stalvey | Stambaugh | Stanaland |
| Stancel | Standford | Standley | Stanfield | Stanford | Stanland | Stanley |
| Stanten | Stantford | Stanton | Staples | Stark | Stark, | Starke |
| Starling | Starling Wall | Starman | Starnes | Starns | Staten | Stebbings |
| Stebbins | Steele | Steffen | Steinbach | Stellman | Stemmon | Step |
| stepens | Stephan | Stephen | Stephens | Stephenson | Sterling | Sterne |
| Sternhberger | Stevens | Stevenson | Stew | Stewart | Stickle | Stidham |
| Stiffler | Still | Stiller | Stimpson | Stine | Stocks | Stockton |
| Stokes | Stone | Store | Storey | Storman | Storter | Story |
| Stout | Stovall | Stover | Stowell | Strabenisky | Stratton | Strayer |
| Stricking | Strickland | Stringer | Stringfellow | Strobhar | Stroble | Strode |
| Strong | Stroud | Stroup | Stuart | Stubbs | Stucky | Stulpner |
| Sturges | Sturgill | Sturgis | Styles | Styres | Suber | Sufford |
| Suggs | Sullivan | Sullivant | Sumerall | Sumeralls | Sumerals | Sumerlin |
| Summeral | Summerall | Summeralls | Summerals | Summerlen | Summerlin | Summerlins |
| Summers | Summural | Sumner | Sumroles | Suney | Sunseri | Surgener |
| Surgerior | Surginer | Surgoner | Surgurner | Surrency | Sushil | Suther |
| Sutherland | Sutton | Swain | Swann | Swayne | Swearingen | Swearinger |
| Sweat | Sweat, | Sweeny | Sweet | Sweetzer | Swertyer | Swift |
| Swilley | Swindall | Swindle | Swint | Swisher | Sykes | Syl |
| Sylcox | Sylvania | Sylve | Sylvester | Sylvister | Symms | Symnadocia |
| Syssen | Tabor | Taft | Tailey | Talavast | Tallahassee | Talley |