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Contributed by Eleanor Colson
On road used 1690 by Spanish explorer Alonso de Leon. In 1821 Andrew Millican began settlement. Henry Fanthorp opened his inn 1834, a post office 1835. Kenneth Anderson, last Vice-President, Republic of Texas, died at Fanthorp's, 1845. After his burial here town was named for him. County created and organized 1846. Named in honor of Jesse Grimes (1788-1866), a signer of Declaration of Independence and member of Congress, Republic of Texas. Anderson was made the county seat. During Civil War, 1861-1865, had a gun factory, furnished troops, food, cotton.